| 57933 | Q9I9L7 | CASPA_DANRE | Caspase a (EC 3.4.22.36) [Cleaved into: Caspase a subunit p20; Caspase a subunit p10] | DISRUPTION PHENOTYPE | Morpholino knockdown in early embryos results in abnormalities in the development of the cartilaginous pharyngeal skeleton and eventually results in death upon exhaustion of the yolk (PubMed:12464617). Abnormalities include deformed and thinned Meckel's and palatoquadrate cartilages, deformed ceratohyal cartilages and disorganized branchial cartilages (PubMed:12464617). Morpholino knockdown in one- to four-cell stage embryos results in an open mouth phenotype (PubMed:12464617). Morpholino knockdown in one-cell embryos results in reduced survival in response to bacterial infection with E.tarda, but does not decrease caspb activation (PubMed:30150286). Morpholino knockdown in larvae results in no abnormalities in the brain, eyes or pectoral fins (PubMed:12464617). {ECO:0000269|PubMed:12464617, ECO:0000269|PubMed:30150286}. |