Mine Disruption Phenotype

Gene Info

  • Species:Zebrafish (Danio rerio)
  • GeneID:793290
  • Symbol:spred2b
  • Description:sprouty related EVH1 domain containing 2b
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Gene ID Entry Entry Name Protein Name Type Information
793290 Q6NYK3 SPRE2_DANRE Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) DISRUPTION PHENOTYPE Morpholino knockdown is associated with increased Erk phosphorylation levels and results in a high incidence of embryos showing delayed gastrulation, or delay in elongation during the segmentation stage, with reduced formation of the head and tailbud. Morphants show yolk elongation at 12 hours post-fertilization, indicating enhanced MAPK signaling. {ECO:0000269|PubMed:34626534}.