Mine Disruption Phenotype

Gene Info

  • Species:Zebrafish (Danio rerio)
  • GeneID:799071
  • Symbol:coq8b
  • Description:coenzyme Q8B
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Gene ID Entry Entry Name Protein Name Type Information
799071 A3QJU3 COQ8B_DANRE Atypical kinase COQ8B, mitochondrial (EC 2.7.-.-) (AarF domain-containing protein kinase 4) (Coenzyme Q protein 8B) DISRUPTION PHENOTYPE Morpholino knockdown of the protein causes nephrosis phenotype of periorbital edema and total body edema in 54% of embryos at 120 hpf. The glomerular structures are altered, with podocyte foot process effacement and disorganization, rarefaction of slit membranes, and disorganization of the glomerular basement membranes. {ECO:0000269|PubMed:24270420}.